GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7267979 | 1 | rs6050632 | chr20:25432601 | FAM182B | chr20:25744102-25848786:- | 0.25 | 5.25 | 2.3E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6050632 | chr20:25432601 | NINL | chr20:25433338-25566153:- | -0.34 | -7.11 | 4.29E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6050632 | chr20:25432601 | PYGB | chr20:25228706-25278647:+ | -0.15 | -3.78 | 0.000174 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs6051080 | 1 | rs6051080 | chr20:25975674 | FAM182A | chr20:26035250-26067552:+ | 0.19 | 3.59 | 0.000369 | Colorectal or endometrial cancer |
| THCA | cis | rs6051080 | 1 | rs6051080 | chr20:25975674 | FAM182B | chr20:25744102-25848786:- | 0.59 | 14.87 | 2.25E-41 | Colorectal or endometrial cancer |
| THCA | cis | rs9876781 | 1 | rs60512868 | chr3:48483445 | ATRIP | chr3:48488141-48507708:+ | 0.19 | 4.22 | 2.93E-5 | Longevity |
| THCA | cis | rs9876781 | 1 | rs60512868 | chr3:48483445 | TREX1 | chr3:48501186-48509043:+ | -0.25 | -5.72 | 1.88E-8 | Longevity |
| THCA | cis | rs965469 | 1 | rs6051672 | chr20:3224819 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.76 | 1.54E-8 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6051702 | chr20:3251924 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.87 | 8.02E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6051703 | chr20:3252347 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.87 | 8.02E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6051705 | chr20:3253143 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.87 | 8.02E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6051708 | chr20:3262493 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.74 | 1.66E-8 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6051709 | chr20:3263685 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.92 | 6.32E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6051712 | chr20:3265029 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.92 | 6.32E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6051713 | chr20:3265779 | ITPA | chr20:3190056-3204504:+ | 0.23 | 5.65 | 2.76E-8 | IFN-related cytopenia |